RESUMO
OBJECTIVE: After 131I treatment in patients with differentiated thyroid carcinoma (DTC), we sometimes find a star-shaped intense uptake of 131I on therapeutic whole body scans (Rx-WBS), called star artifacts. Therefore, we analyzed the relevant clinical factors and prognostic value of star artifacts in DTC patients. METHODS: 809 DTC patients who received 131I treatment were retrospectively evaluated and divided into 2 groups of patients with and without star artifacts. We evaluated the therapeutic response which was divided into excellent response (ER), biochemical incomplete response (BIR), indeterminate response (IR), and structural incomplete response (SIR). Clinical factors for the presence of star artifacts were analyzed. We also compared the rate of ER, BIR, IR, SIR and recurrence rate between group 1 and group 2. RESULTS: The major clinical factors included stimulated thyroglobulin (sTg)>1.8ng/ml, 24h radioiodine uptake (RAIU)>2.2%, and positive 99mTcO4- thyroid imaging for the presence of star artifacts. In patients with sTg levels>10ng/ml, patients in group 1 had a higher rate of ablation success and ER than patients in group 2 (80.2% vs 65.6%, P=0.038, 31.6% vs 13.1%, P=0.008, respectively) and had a similar rate of BIR, IR, SIR. Recurrence rate was similar between group 1 and group 2 (5.2% vs 3.1%, P=0.13). CONCLUSION: More remnant thyroid tissue is one of the factors associated with the presence of star artifacts on Rx-WBS. Patients with star artifacts exhibit a better therapeutic response (ER) when sTg levels are >10ng/ml. However, star artifacts have no effect on the recurrence rate.
RESUMO
La invasión traqueal por carcinomas tiroideos bien diferenciados es poco frecuente y la técnica quirúrgica a realizar todavía es motivo de controversia entre los cirujanos. El objetivo del artículo fue revisar la literatura disponible sobre la invasión traqueal por carcinomas diferenciados del tiroides. Se realizó una revisión bibliográfica en PubMed/Medlinede la literatura relacionada con la invasión traqueal por carcinomas diferenciados del tiroides(2000 - 2016). Se utilizaron las siguientes palabras y frases clave en inglés: thyroid, carcinoma, differentiated thyroid cancer, tracheal invasión y las correspondientes a su traducción al español. No se encontraron ensayos clínicos aleatorizados. La mayoría de los artículos fueron de carácter retrospectivo. Se evaluaron las características clínicas de la lesión y los métodos de diagnóstico: laringotraqueoscopia, citología aspirativa y estudios imaginológicos. Se definieron las indicaciones quirúrgicas y los cuidados de anestesiología. Por último, se realizóla discusión crítica de los métodos de diagnóstico y de las técnicas quirúrgicas utilizadas y el valor e indicación de cada una de estas. El cuadro clínico, la traqueoscopia, la imaginología y el estudio citopatológico son fundamentales para establecer el diagnóstico preoperatorio. Siempre que sea posible,la resección circunferencial de la tráquea debe ser la técnica de elección en el tratamiento de pacientes afectados por infiltración traqueal por carcinomas tiroideos diferenciados(AU)
Tracheal invasion by differentiated thyroid carcinomas is rare and surgical technique to be performed is still controversial among surgeons. The aim of this article was to review the available literature on the tracheal invasion by differentiated thyroid carcinomas. A literature review on the literature related to tracheal invasion by differentiated thyroid carcinomas (- 2016 2000) was performed in PubMed / MEDLINE. The following keywords and phrases in English were used: thyroid, carcinoma, differentiated thyroid cancer, tracheal invasion and their corresponding translation into Spanish. No randomized clinical trials were found. Most articles were retrospective. Clinical characteristics of this lesion and its diagnostic methods were evaluated: laryngo-tracheoscopy, aspiration cytology, and imaging studies: clinical characteristics of the lesion and diagnostic methods were evaluated. Surgical indications and anesthesiology care were defined. Finally, a critical discussion was made on the diagnostic methods and surgical techniques used and the value and indication of each. The clinical condition, the tracheoscopy, imaging and cytopathology study are essential to establish the preoperative diagnosis. Wherever possible, the circumferential resection of the trachea should be the technique of choice in the treatment of patients with tracheal infiltration by differentiated thyroid carcinomas(AU)
Assuntos
Humanos , Neoplasias da Glândula Tireoide/cirurgia , Literatura de Revisão como Assunto , Técnicas Citológicas , Diagnóstico Diferencial , Ultrassonografia/métodosRESUMO
La invasión traqueal por carcinomas tiroideos bien diferenciados es poco frecuente y la técnica quirúrgica a realizar todavía es motivo de controversia entre los cirujanos. El objetivo del artículo fue revisar la literatura disponible sobre la invasión traqueal por carcinomas diferenciados del tiroides. Se realizó una revisión bibliográfica en PubMed/Medlinede la literatura relacionada con la invasión traqueal por carcinomas diferenciados del tiroides(2000 - 2016). Se utilizaron las siguientes palabras y frases clave en inglés: thyroid, carcinoma, differentiated thyroid cancer, tracheal invasión y las correspondientes a su traducción al español. No se encontraron ensayos clínicos aleatorizados. La mayoría de los artículos fueron de carácter retrospectivo. Se evaluaron las características clínicas de la lesión y los métodos de diagnóstico: laringotraqueoscopia, citología aspirativa y estudios imaginológicos. Se definieron las indicaciones quirúrgicas y los cuidados de anestesiología. Por último, se realizóla discusión crítica de los métodos de diagnóstico y de las técnicas quirúrgicas utilizadas y el valor e indicación de cada una de estas. El cuadro clínico, la traqueoscopia, la imaginología y el estudio citopatológico son fundamentales para establecer el diagnóstico preoperatorio. Siempre que sea posible,la resección circunferencial de la tráquea debe ser la técnica de elección en el tratamiento de pacientes afectados por infiltración traqueal por carcinomas tiroideos diferenciados(AU)
Tracheal invasion by differentiated thyroid carcinomas is rare and surgical technique to be performed is still controversial among surgeons. The aim of this article was to review the available literature on the tracheal invasion by differentiated thyroid carcinomas. A literature review on the literature related to tracheal invasion by differentiated thyroid carcinomas (- 2016 2000) was performed in PubMed / MEDLINE. The following keywords and phrases in English were used: thyroid, carcinoma, differentiated thyroid cancer, tracheal invasion and their corresponding translation into Spanish. No randomized clinical trials were found. Most articles were retrospective. Clinical characteristics of this lesion and its diagnostic methods were evaluated: laryngo-tracheoscopy, aspiration cytology, and imaging studies: clinical characteristics of the lesion and diagnostic methods were evaluated. Surgical indications and anesthesiology care were defined. Finally, a critical discussion was made on the diagnostic methods and surgical techniques used and the value and indication of each. The clinical condition, the tracheoscopy, imaging and cytopathology study are essential to establish the preoperative diagnosis. Wherever possible, the circumferential resection of the trachea should be the technique of choice in the treatment of patients with tracheal infiltration by differentiated thyroid carcinomas(AU)
